The Girls Aloud star will team up with the Beano bad girl in a series of cartoon strips published from next month.
Dundee-based publishers DC Thomson spotted her sporting a red and black striped outfit in her video for “Fight For This Love.”
The X Factor judge, who recently split from footballer husband Ashley Cole, had her Beano-style jumper designed by late fashion designer Alexander McQueen.
Creators of the long-running Scots comic hope incorporating celebrities like Cole and footballer Wayne Rooney will boost summer holiday sales.
A Beano spokesman said: “Minnie the Minx will be meeting Cheryl and Wayne in a run of stories which will coincide with the school summer holidays.
“They are both hugely popular with readers and I’m sure they’ll be thrilled at the prospect of them coming face to face with a national institution, in the shape of Minnie.”
Cole, 26, will join Minnie in a duet – while Rooney, 24, will risk injury by taking to the field alongside the hard-tackling schoolgirl.
Minnie the Mix has been terrorising teachers in her comic strip since 1953.
Former Dr Who star David Tennant, presenter Jonathan Ross and chef Jamie Oliver have previously starred in DC Thomson’s Dennis the Menace and the Bash Street Kids comics.