This article will discuss PTD-DBM peptide and its potential mechanisms of action. PTD-DBM peptide is an acronym for “Protein Transduction Domain-fused Dishevelled Binding Motif,” the name of a synthetic peptide.
How does PTD-DBM work?
Studies suggest PTD-DBM may only produce its effects by influencing a single system at a time. The Wnt/-catenin signaling pathway is an evolutionarily conserved mechanism that helps maintain cellular homeostasis.
B-catenin is expressed in the dermal papilla, which supports the induction and length of the anagen phase of the cell cycle and the regulation and differentiation of keratinocytes. Because of this, beta-catenin is the protein that is important for the development of healthy hair. [i]
On the other hand, this route is often inhibited due to a cell pathway-linked protein known as CXXC-type zinc finger protein 5 (CXXC5), which performs the function of a negative regulator. The formation of hair follicles is inhibited due to their ability to attach to a different protein known as the disheveled protein.
Research suggests PTD-DBM may be effective because it may inhibit the binding process of CXXC5 by serving as a competitive inhibitor of that protein. After that, the Wnt/-catenin signaling pathway may continue functioning normally. [ii] As a direct consequence, the process of follicular development is accelerated, ultimately resulting in new hair growth.
The findings of research that was carried out on mice suggest the presentation of PTD-DBM may also aid in expediting the healing process of wounds by acting as a regulator of the Wnt/-catenin signaling pathway. This pathway is important for the proliferation and differentiation of dermal cells. [iii]
PTD-DBM Peptide Properties
Scientists hypothesize that because PTD-DBM operates via a very particular mechanism of action, its properties are likewise rather clear and straightforward. Studies in animal test models suggest PTD-DBM may be a preventative measure against hair loss by promoting activity along the Wnt/-catenin signaling pathway. In addition, it may stimulate the production of new hair follicles, encouraging new hair development.
Research suggests androgenetic alopecia, characterized by baldness induced by androgens, may be manageable with PTD-DBM, which has been speculated to be particularly useful in mitigating the impact of the condition on animal test models. [iv]
PTD-DBM has also bee suggested to exhibit potential in accelerating the healing process of wounds and injuries, via the same pathway.
PTD-DBM Peptide vs. Other Peptides
PTD-DBM Peptide vs. Thymosin Beta-4 (TB4) Peptide
PTD-DBM and Thymosin Beta-4 are peptides that have suggested the ability to hasten the wound-healing process. Nevertheless, studies suggest their workings are distinct.
Researchers speculate Thymosin Beta-4 may be a naturally occurring peptide that may directly promote stem cell proliferation; in contrast, PTD-DBM is a synthetic peptide that may indirectly exert its action via modulating the Wnt/-catenin signaling pathway, and is designed and limited to use in a laboratory.
PTD-DBM Peptide vs. GHK-Cu Peptide
Scientists hypothesize PTD-DBM, and GHK-Cu are examples of peptides that may be researched in relation to hair loss due to their potential role in the regeneration of hair follicles and, therefore, the prevention of further hair loss.
On the one hand, PTD-DBM is a synthetic peptide, while on the other, GHK-Cu is something that can be found naturally in fluids such as saliva and urine.
PTD-DBM Peptide vs. Zn-Thymulin Peptide
Androgenic alopecia is thought to be caused by high amounts of dihydrotestosterone. Studies in animal test models suggest these peptides are designed to combat this condition, but their points of origin are distinct.
PTD-DBM is a peptide generated in a lab, while Zn-Thymulin is a hormone made naturally by thymic epithelial cells and is a nonapeptide.
Research suggests PTD-DBM may be responsible for the regeneration of hair fibers.It is also speculated that PTD-DBM may have wound-healing characteristics; however, this hypothesis needs to be investigated further via prolonged scientific study.
Because insufficient information is available, ingesting peptides poses a risk. The peptides mentioned in this article are not approved for human consumption and should only be utilized in laboratory settings by academics or people qualified to do so. Any bodily introduction of any kind is strictly prohibited. Biotech Peptides is an excellent resource for reputable, high quality peptides for research.
References
[i] Bejaoui, M., Villareal, M. O., & Isoda, H. (2019). ?-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid. Aging, 11(12), 4216–4237. https://doi.org/10.18632/aging.102048
[ii] Lee, S. H., Seo, S. H., Lee, D. H., Pi, L. Q., Lee, W. S., & Choi, K. Y. (2017). Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. The Journal of investigative dermatology, 137(11), 2260–2269. https://doi.org/10.1016/j.jid.2017.04.038
[iii] Lee, S. H., Kim, M. Y., Kim, H. Y., Lee, Y. M., Kim, H., Nam, K. A., Roh, M. R., Min, doS., Chung, K. Y., & Choi, K. Y. (2015). The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. The Journal of experimental medicine, 212(7), 1061–1080. https://doi.org/10.1084/jem.2014160
[iv] Ryu, Y. C., Park, J., Kim, Y. R., Choi, S., Kim, G. U., Kim, E., Hwang, Y., Kim, H., Han, G., Lee, S. H., & Choi, K. Y. (2023). CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2. Cells, 12(4), 555. https://doi.org/10.3390/cells12040555
